Project A01

The role of complement and its crosstalk with toll-like receptor-signalling in the adrenal gland dysregulation during sepsis

Sorry here should be a picture of WKanczkowski_SBornstein_A01 CRCTRR 205

Dr. rer. med. Waldemar Kanczkowski 

waldemar.kanczkowski(at)uniklinikum-dresden.de
Department of Internal Medicine III, Endocrinology,
University Hospital Carl Gustav Carus Dresden,
Technische Universität Dresden

Prof. Dr. med. R. Stefan Bornstein
stefan.bornstein(at)uniklinikum-dresden.de
Department of Internal Medicine III,
University Hospital Carl Gustav Carus Dresden,
Technische Universität Dresden

Scientific staff

Alexia Belavgeni –  PhD Student
Maria Schuster  – TA
Uta Lehnert –  TA

Project Description


Sepsis remains a major health problem in the world. Project A01 deals with the role of the dysregulated immune system in adrenal dysfunction in patients with sepsis. Special emphasis is placed on the role of the complement system and its proinflammatory mediators (C3a and C5a – anaphylatoxins), which are known to contribute to the sepsis-mediated multiorgan failure. It specifically focuses on the C3a-C3aR- and C5a-C5aR- signaling with the aim to understand underlying mechanisms and to establish therapeutic interventions for sepsis.

Aims

(I) Characterise the role of the complement activation and cellular targets of C3a and C5a anaphylatoxins within adrenal microenvironment in vivo during caecal ligation and puncture (CLP)-induced sepsis and in vitro using primary adrenal cell cultures.

(II) Define the role of cell-specific toll-like receptor signalling in the complement activation and their crosstalk during CLP-mediated adrenal gland dysfunction.

(III) Test the effect of complement inhibition on CLP-mediated adrenal gland dysfunction.

PhD/MD-Thesis

PhD candidate Alexia Belavgeni. Starting date – 10.2017.
The role of complement system in the adrenal gland dysfunction of adrenal gland during sepsis.