Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model
Prof. Dr. med. Triantafyllos Chavakis
Institute of Clinical Chemistry and Laboratory Medicine
University Hospital Carl Gustav Carus Dresden
Technische Universität Dresden
Ales Neuwirth – Postdoc
Project A03 focuses on the establishment of the first model of autoimmune adrenalitis. Autoimmune adrenalitis is the primary reason for adrenal insufficiency. It is caused by autoreactive immune cells resulting from disruption of immune tolerance. The planned model would be of major importance in understanding the disease pathophysiology. We aim at engaging this model to understand the relevance of different autoimmune mechanisms in disease pathogenesis.
(I) Generate and characterise in detail the experimental autoimmune adrenalitis (EAA) model.
(II) Understand underlying auto-immune mechanisms of EAA.
(III) Study the role of immunomodulatory interventions in the context of EAA.