Our Clinician Scientist Profile: Irina Chifu

Irina Chifu, Clinician Scientist, Adrenal Research CRC/TRR205

Irina Chifu     

University Hospital of Würzburg     

State exam: 2014, University Hospital “Gr. T. Popa” Iasi, Romania

Diploma thesis: “Outcome of Growth Hormone Replacement on Children with Growth Hormone Deficiency”, Iasi, Romania, 2014.

Dissertation: “Chemokine Expression in Benign and Malignant Adrenal Tumors”, University Hospital of Würzburg (in progress)

Research theme: Adrenal insufficiency     

  1. Registry for patients with chronic adrenal insufficiency: prospective and retrospective analysis of morbidity/comorbidities/mortality, adrenal crises, patient subpopulations and quality of life; establishing new parameters/algorithms to assess the quality of the replacement therapy and provide a personalized therapy
  2. Assessment of tissue sodium content by 23Na-MRI in patients with primary adrenal insufficiency
  3. Extent of liver fatty degeneration and liver fibrosis under replacement therapy with glucocorticoids in adrenal insufficiency (coordinated by University Hospital Frankfurt)

Publications:

Fenske W, Refardt J, Chifu I  et al. A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. N Engl J Med 2018; 379:428-439. doi: 10.1056/NEJMoa1803760    

Refardt J, Sailer CO, Winzeler B, Betz MJ, Chifu I, Schnyder I, Fassnacht M, Fenske W, Christ-Crain M. FGF-21 levels in polyuria-polydipsia syndrome. Endocr Connect. 7(12):1501-1506. doi: 10.1530/EC-18-0469.

Awards:
2018: Poster prize of the DGE, 13. Deutsche Nebennierenkonferenz der Sektion Nebenniere, Steroide und Hypertonus 2018